Changes in the blood indicators of experimental animals by introduction of the components based on lanthanide ions and calcium into the zone of a femoral fracture

Akhtyamov I.F., Shakirova F.V., Korobeynikova D.A., Han H.Z., Sidoruk E.I.


Reduction of time to restore bone integrity remains one of the main problems in traumatology and orthopedics. To solve this problem, various kinds of components have been used, one of which are bisphosphonates. This article presents an experiment, the purpose of which was to study the effect of components based on etidronates of lanthanide or calcium on blood indicators by different ways of their introduction into the femoral fracture site in experimental animals.
Materials and methods
Studies were conducted on 75 male rats aged 5–6 months, weighing 300–350 g. A femoral fracture was modeled in all animals, and retrograde intramedullary osteosynthesis was performed. Animals were divided into 5 groups. Group 1 received no components; a component based on etidronates of lanthanide and calcium was introduced in group 2 through a catheter; group 3 had paraossal administration of etidronates of lanthanide and calcium; group 4 had paraossal introduction of a component based on etidronate calcium through a catheter; and group 5 had introduction of components based on etidronates and calcium. Animals received the investigated components twice in the fracture zone on days 3 and 5 after the operation, except the comparison group.
In groups with a catheter, the most pronounced local inflammatory response was observed. Changes in hemoglobin concentration were observed in all groups, in the early (7 days) period. It was found that in rats which were injected with components containing lanthanides, the average content of hemoglobin, erythrocytes and leukocytes were identical to those of group 1.
The study revealed that the components, which include lanthanide ions do not cause negative changes in the rat blood according to hematological tests.


rat, femoral bone, hematological values

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