Current approaches to diagnosis of fracture consolidation disorders

Miromanov A.M., Gusev K.A., Uskov S.A., Davydov S.O., Miromanova N.A.

Abstract


Purpose
Identification of personalized diagnostic criteria of consolidation disorders in limb bone fractures.
Materials and methods
108 patients at the age from 20 to 40 years (according to WHO classification) with limb bone fractures were included into the study. Group 1 were patients (n = 62) with uncomplicated fractures. Group 2 (n = 46) included patients with consolidation disorders. The presence of acute or chronic associated diseases was the exclusion criteria. Clinical, laboratory and instrumentation findings (210 parameters) were assessed in a multivariate predictive regression model. These parameters were studied at admission, then on days 2, 5, 10 and 90 of the study. Statistic processing was performed using STATISTICA 6.1 software package (StatSoft, Russia).
Results
The multivariate regression analysis used revealed high association of -25Pro/Pro genotype of TGFβ1 gene and -2073Т/T genotype of EGFR-2073A > T gene in patients with consolidation disorders that ran as delayed consolidation type (p less 0.0000001).
Conclusion
The combination of genotypes -25Pro/Pro of TGFβ1 gene and -2073Т/T of EGFR gene can be used as one of the markers of consolidation disorder in limb bone fractures, and that will enable to use personalized prophylactic programs to prevent such complications.

Keywords


fractures, consolidation disorder, polymorphism, genes, prediction

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