Comparative characterization of microorganism species composition for chronic posttraumatic and hematogenous osteomyelitis

Розова Л.В., Годовых Н.В.

Abstract


Purpose. Comparative characterization of the species composition of microorganisms in patients with chronic posttraumatic and hematogenous osteomyelitis.
Material and Methods. The results of microbiological investigation of the wound discharge analyzed in 56 patients with chronic posttraumatic osteomyelitis, and in 13 patients with chronic hematogenous osteomyelitis.
Results. The microcenosis structure in patients with chronic posttraumatic osteomyelitis characterized by the increase in bacterial species variety comparing with hematogenous osteomyelitis, and it differed by a great number of isolated gram-negative bacteria having high persistent potential, thereby leading to long duration of purulent infection. Nevertheless, S. aureus is the main pathogen of purulent process in the groups studied, being isolated in association with gram-negative microflora in 72.7% for chronic posttraumatic osteomyelitis, and in 100.0% – for hematogenous osteomyelitis, and, what is more, isolated with P. aeruginosa in 45.5% and 75.0% of cases, respectively. In the investigations of cases with chronic posttraumatic and hematogenous osteomyelitis the revealed microorganisms can form biofilms in the inflammation focus which protect bacteria from exposure to the immune response and antibacterials.
Conclusion. Timely microbiological diagnostics, efficient antibacterial therapy, prevention of forming biofilms, that is early suppression of their formation using various antimicrobial agents and modern methodical approaches – all this plays an important role in successful treatment of chronic osteomyelitis together with traditional surgical methods.

Keywords


chronic posttraumatic and hematogenous osteomyelitis, microorganisms, associations, biofilms

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