RADIONUCLIDE EVALUATION OF DISTRACTIONAL OSTEOGENESIS IN THE PROCESS OF SUBSTITUTION OF LOWER LIMB BONE DEFECTS IN PATIENTS WITH GIANT-CELL

Куфтырев Л.М., Пожарищенский К.Э., Носова Л.Н., Свешников А.А., Балаев И.И., Ларионова Т.А., Офицерова Н.В.

Abstract


A giant-cell tumor was removed and a bone tissue defect was substituted by transportation of bone fragments in 14 patients. Osteogenesis status was controlled using labelled Technephor, and concentration of osteotropic hormones and cyclic nucleotides was studied as well. It was established, that the process of regeneration in oncological patients was lower, than in patients without tumors. Parathyrin amounts were more in oncological patients at osteosynthesis stages. Concentration of calcitonin and somatotropin was considerably less. On the basis of cAMP/cGMP ratio study it was noted, that organotypical reorganization of distraction regenerate was longer, when postresection defects were substituted in comparison with posttraumatic ones.

Keywords


lower limb, giant-cell tumor, transosseous osteosynthesis, osteogenesis, radionuclide diagnostics

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